METUGE SAMUEL
PhD student, University of Buea
Title: PHYTOCHEMICAL CHARACTERIZATION AND POTENTIAL ANTIDIABETIC NUTRACEUTICAL PROPERTIES OF IRVINGIA GABONENSIS (BUSH MANGO)
Biography
Biography: METUGE SAMUEL
Abstract
Nutraceuticals are products, which other than nutrition are also used as medicine. The phytochemical components of many medicinal plants have most often been linked to the modulation of biomarkers associated to diabetes type 2. This study was aimed characterizing the phytochemical components and evaluating the anti diabetic nutraceutical properties of Irvingia gabonensis.
Extracts of Irvingia gabonensis were prepared and used for the nutritional and phytochemical analysis in vitro. The most active extracts were selected for the evaluation of in vitro nutritional and phytochemical analysis, as well as in vivo acute toxicity and their effects on antihyperglycemic test - blood glucose levels. In addition, the preventive effects of the extracts against some biomarkers of diabetes (body weight, fasting blood glucose,) were evaluated at varied doses.
Phytochemical screening revealed the presence of alkaloids, tannins, phenols and flavanoids in all extracts. The most important nutrients were Proteins, Lipids, Sugars and a range of minerals. Anti radical effect at DPPH and ABTS for IC50 were ABTS(IC50) = 3.55 ±0.17 and DPPH(IC50) = 2.22 ± 0.02. Inhibitory effects were best at concentration of 20mg/ml for DPPH and conc of 10mg/ml for ABTS. Proximate analysis revealed nutrient contents at p≤0.0001 similar to the Turkey test. In addition, the extract showed anti hyperglycemic effects as the normoglycemia showed active results at 90 minuits interval at a dode of 500mg/kg of extract upon administration on wister rats.
These results suggest that Irvingia gabonensis is a very rich nutrient food and poses a wide range of phytochemicals that can have anti glycemic activity, thus having Nutraceutical properties with potential in the of treatment of Diabetes